Adult-onset of Langerhans cell histiocytosis: a clinical case

Langerhans cell histiocytosis is mainly diagnosed in children, and its manifestation adult age quite uncommon. Skin rashes may be non-specific mimic a number of dermatoses. Therefore, the clinical diagnosis challenging as rule, such patients are misinterpreted managed for other disorders by dermatologist some years.
 We present case with skin involvement 35-year female patient, who had been treated 2 years pyoderma, seborrheic dermatitis, fold candidiasis. Taking into account signs symptoms manifestation, we initially suspected familial benign pemphigus (Hailey-Hailey disease) or follicular dyskeratosis (Darier's disease). However, histological assessment showed confirmed immunohistochemistry anti-langerin, anti-CD1a, anti-protein S-100 antibodies. The patient was referred to hematologist further work-upand specific treatment.
 In cases any treatment resistant disorders, which do not respond long-term conventional treatment, it necessary reconsider means investigation. It would allow identification disease, uncommon dermatology practice.